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Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance
Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance
- Source :
- The Journal of clinical investigation. 92(1)
- Publication Year :
- 1993
-
Abstract
- To establish whether insulin resistance and/or postprandial fatty acid metabolism might contribute to familial combined hyperlipidemia (FCH) we have examined parameters of insulin resistance and lipid metabolism in six FCH kindreds. Probands and relatives (n = 56) were divided into three tertiles on the basis of fasting plasma triglycerides (TG). Individuals in the highest tertile (TG > 2.5 mM; n = 14) were older and had increased body mass index, systolic blood pressure, and fasting plasma insulin concentrations compared with individuals in the lowest tertile (n = 24). The former also presented with decreased HDL cholesterol and increased total plasma cholesterol, HDL-TG, and apoprotein B, E, and CIII concentrations. Insulin concentrations were positively correlated with plasma apo B, apo CIII, apo E, and TG, and inversely with HDL cholesterol. Fasting nonesterified fatty acids (NEFA) were elevated in FCH subjects compared to six unrelated controls and five subjects with familial hypertriglyceridemia. Prolonged and exaggerated postprandial plasma NEFA concentrations were found in five hypertriglyceridemic FCH probands. In FCH the X2 minor allele of the AI-CIII-AIV gene cluster was associated with increased fasting plasma TG, apo CIII, apo AI, and NEFA concentrations and decreased postheparin lipolytic activities. The clustering of risk factors associated with insulin resistance in FCH indicates a common metabolic basis for the FCH phenotype and the syndrome of insulin resistance probably mediated by an impaired fatty acid metabolism.
- Subjects :
- Male
medicine.medical_specialty
Apolipoprotein B
Genetic Linkage
medicine.medical_treatment
Hyperlipidemia, Familial Combined
chemistry.chemical_compound
NEFA
Insulin resistance
Internal medicine
medicine
Humans
Insulin
Apolipoproteins B
biology
Fatty acid metabolism
Cholesterol
Fatty Acids
General Medicine
medicine.disease
Familial hypertriglyceridemia
Pedigree
Postprandial
Endocrinology
chemistry
biology.protein
lipids (amino acids, peptides, and proteins)
Female
Insulin Resistance
Polymorphism, Restriction Fragment Length
Research Article
Subjects
Details
- ISSN :
- 00219738
- Volume :
- 92
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical investigation
- Accession number :
- edsair.doi.dedup.....dc35d598c0cdc50e835b10115520fdc0