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A multi-metric registration strategy for the alignment of longitudinal brain images in pediatric oncology
- Source :
- Medicalbiological engineeringcomputing. 58(4)
- Publication Year :
- 2019
-
Abstract
- Survival of pediatric patients with brain tumor has increased over the past 20 years, and increasing evidence of iatrogenic toxicities has been reported. In follow-ups, images are acquired at different time points where substantial changes of brain morphology occur, due to childhood physiological development and treatment effects. To address the image registration complexity, we propose two multi-metric approaches (Mplus, Mdot), combining mutual information (MI) and normalized gradient field filter (NGF). The registration performance of the proposed metrics was assessed on a simulated dataset (Brainweb) and compared with those obtained by MI and NGF separately, using mean magnitude and mean angular errors. The most promising metric (Mplus) was then selected and tested on a retrospective dataset comprising 45 pediatric patients who underwent focal radiotherapy for brain cancer. The quality of the realignment was scored by a radiation oncologist using a perceived misalignment metric (PM). All patients but one were assessed as PM ≤ 2 (good alignment), but the remaining one, severely affected by hydrocephalus and pneumocephalus at the first MRI acquisition, scored PM = 5 (unacceptable). These preliminary findings suggest that Mplus might improve the registration accuracy in complex applications such as pediatric oncology, when data are acquired throughout the years of follow-up, and is worth investigating.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Biomedical Engineering
Brain tumor
Deformable registration
Image registration
Image Processing, Computer-Assisted
Medicine
Humans
Child
Normalized gradient field
Radiation oncologist
Retrospective Studies
business.industry
Brain Neoplasms
Brain morphometry
Mutual information
medicine.disease
Magnetic Resonance Imaging
Computer Science Applications
Hydrocephalus
Pediatric brain tumors
Radiation therapy
Brain MRI
Child, Preschool
Radiology
Metric (unit)
business
Subjects
Details
- ISSN :
- 17410444
- Volume :
- 58
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Medicalbiological engineeringcomputing
- Accession number :
- edsair.doi.dedup.....dc34e8d34c4421850b795eb70b472821