Back to Search
Start Over
The neglected challenge: Vaccination against rickettsiae
- Source :
- PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008704 (2020), PLoS Neglected Tropical Diseases
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Over the last decades, rickettsioses are emerging worldwide. These diseases are caused by intracellular bacteria. Although rickettsioses can be treated with antibiotics, a vaccine against rickettsiae is highly desired for several reasons. Rickettsioses are highly prevalent, especially in poor countries, and there are indications of the development of antibiotic resistance. In addition, some rickettsiae can persist and cause recurrent disease. The development of a vaccine requires the understanding of the immune mechanisms that are involved in protection as well as in immunopathology. Knowledge about these immune responses is accumulating, and efforts have been undertaken to identify antigenic components of rickettsiae that may be useful as a vaccine. This review provides an overview on current knowledge of adaptive immunity against rickettsiae, which is essential for defense, rickettsial antigens that have been identified so far, and on vaccination strategies that have been used in animal models of rickettsial infections.
- Subjects :
- 0301 basic medicine
Physiology
Antibiotics
RC955-962
Orienta Tsutsugamushi
Review
Adaptive Immunity
Pathology and Laboratory Medicine
Communicable Diseases, Emerging
Biochemistry
White Blood Cells
0302 clinical medicine
Animal Cells
Immune Physiology
Immunopathology
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Medicine
Public and Occupational Health
Rickettsia
Immune System Proteins
biology
T Cells
Animal Models
Rickettsia rickettsii
Acquired immune system
Vaccination and Immunization
Bacterial Pathogens
Vaccination
Infectious Diseases
Experimental Organism Systems
Medical Microbiology
Bacterial Vaccines
Cellular Types
Pathogens
Public aspects of medicine
RA1-1270
medicine.drug_class
Immune Cells
Immunology
030231 tropical medicine
Cytotoxic T cells
Mouse Models
Research and Analysis Methods
Microbiology
Antibodies
03 medical and health sciences
Model Organisms
Antibiotic resistance
Immune system
Rickettsiaceae
Rickettsia Rickettsii
Humans
Microbial Pathogens
Blood Cells
Bacteria
business.industry
Intracellular parasite
Organisms
Public Health, Environmental and Occupational Health
Biology and Life Sciences
Proteins
Rickettsia Infections
Rickettsia Prowazekii
Cell Biology
biology.organism_classification
030104 developmental biology
Animal Studies
bacteria
Preventive Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....dc33f02da02c8aaab85e8756069ca9d4