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Mycobacterium tuberculosis infection among persons who inject drugs in San Diego, California
- Source :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol 21, iss 4, Armenta, RF; Collins, KM; Strathdee, SA; Bulterys, MA; Munoz, F; Cuevas-Mota, J; et al.(2017). Mycobacterium tuberculosis infection among persons who inject drugs in San Diego, California. International Journal of Tuberculosis and Lung Disease, 21(4), 425-431. doi: 10.5588/ijtld.16.0434. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4gn1655m
- Publication Year :
- 2017
- Publisher :
- International Union Against Tuberculosis and Lung Disease, 2017.
-
Abstract
- Author(s): Armenta, RF; Collins, KM; Strathdee, SA; Bulterys, MA; Munoz, F; Cuevas-Mota, J; Chiles, P; Garfein, RS | Abstract: BackgroundPersons who inject drugs (PWID) might be at increased risk for Mycobacterium tuberculosis infection and reactivation of latent tuberculous infection (LTBI) due to their injection drug use.ObjectivesTo determine prevalence and correlates of M. tuberculosis infection among PWID in San Diego, California, USA.MethodsPWID aged 18 years underwent standardized interviews and serologic testing using an interferon-gamma release assay (IGRA) for LTBI and rapid point-of-care assays for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections. Independent correlates of M. tuberculosis infection were identified using multivariable log-binomial regression.ResultsA total of 500 participants met the eligibility criteria. The mean age was 43.2 years (standard deviation 11.6); most subjects were White (52%) or Hispanic (30.8%), and male (75%). Overall, 86.7% reported having ever traveled to Mexico. Prevalence of M. tuberculosis infection was 23.6%; 0.8% were co-infected with HIV and 81.7% were co-infected with HCV. Almost all participants (95%) had been previously tested for M. tuberculosis; 7.6% had been previously told they were infected. M. tuberculosis infection was independently associated with being Hispanic, having longer injection histories, testing HCV-positive, and correctly reporting that people with 'sleeping' TB cannot infect others.ConclusionsStrategies are needed to increase awareness about and treatment for M. tuberculosis infection among PWID in the US/Mexico border region.
- Subjects :
- Male
Cross-sectional study
HIV Infections
Cardiorespiratory Medicine and Haematology
California
Hepatitis
Serology
Substance Misuse
0302 clinical medicine
injection drug use
Risk Factors
Prevalence
80 and over
2.2 Factors relating to the physical environment
030212 general & internal medicine
Aetiology
latent tuberculous infection
Travel
biology
Latent tuberculosis
Coinfection
Liver Disease
05 social sciences
Substance Abuse
Hepatitis C
Middle Aged
Infectious Diseases
QuantiFERON((R))-TB Gold In-Tube assay
HIV/AIDS
Female
Intravenous
Infection
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Tuberculosis
Adolescent
Point-of-Care Systems
Chronic Liver Disease and Cirrhosis
Microbiology
Article
Mycobacterium tuberculosis
Young Adult
03 medical and health sciences
Rare Diseases
Hepatitis - C
Tuberculosis diagnosis
Latent Tuberculosis
Clinical Research
Internal medicine
0502 economics and business
medicine
Humans
PWID
Aged
business.industry
HIV
medicine.disease
biology.organism_classification
Virology
Cross-Sectional Studies
Emerging Infectious Diseases
Good Health and Well Being
050211 marketing
Digestive Diseases
Drug Abuse (NIDA only)
business
Interferon-gamma Release Tests
Subjects
Details
- ISSN :
- 10273719
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- The International Journal of Tuberculosis and Lung Disease
- Accession number :
- edsair.doi.dedup.....dc2e21e08e257f7e2a42f13b9b05f883