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A study on the expression of erbB4/HER4 in non-small cell lung cancer
- Source :
- The Chinese-German Journal of Clinical Oncology. 7:75-77
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- To detect the expression of human epidermal-growth-factor receptor 4 (HER4) and elucidate the relationship between its overexpression and the clinicopathological characteristics in non-small cell lung cancer (NSCLC).The expression of HER4 was detected in 70 cases of paraffin-embedded NSCLC tissues by immunohistochemical assay.HER4 were overexpressed in 91.4% of NSCLC. The overexpression of HER4 was significantly related to lymph node metastasis (P=0.007), TNM stages (P=0.011) and postoperative survival rate (P= 0.0258).erbB4 is one of the genes to regulate the growth of advanced NSCLC. The artificial interference with HER4 overexpression may be a good way in the treatment of advanced NSCLC.
Details
- ISSN :
- 16139089 and 16101979
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- The Chinese-German Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....dc2b65ce68de76f831cca972cb766ecf