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Immunomodulatory Effect of Sasa quelpaertensis Leaves Fermentation Products in Mice
- Source :
- Fermentation, Volume 7, Issue 3, Fermentation, Vol 7, Iss 142, p 142 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- The purpose of this study was to enhance the immune-enhancing activity of mushroom strains through fermentation to promote food use of leaf extracts of S. quelpaertensis containing β-glucan. We evaluated the immunomodulatory effect of extracts from fermented S. quelpaertensis leaves (SQGL, SQHE, SQPL). S. quelpaertensis leaves fermentation products were prepared by using mushroom mycelia (Ganoderma lucidum, Hericium erinaceum, Phellinus linteus). The content of β-glucan, a major substance in S. quelpaertensis leaves fermentation products, was 3.73 ± 0.50 mg/mL in the extract (SQ) of S. quelpaertensis leaves. The fermented mushrooms, SQGL, were the highest at 5.57 ± 0.86 mg/100 mL, followed by SQHE and SQPL, and the β-glucan content of all of the glucan was &gt<br />75.3%. To test the immune activity, S. quelpaertensis leaf fermentation products were administered to mice at different doses (60, 160, and 360 mg/kg) for two weeks. Th cell and macrophage populations were found to increase significantly at all three doses compared to the negative control after two weeks. SQGL and SQHE were highest at 160 mg/kg, and SQPL showed the highest Th cell proliferation at 60 mg/kg. In addition, the production of IFN-γ, IL-4, IL-10, and nitric oxide was significantly higher than that of the negative control after two weeks. In particular, an increase was seen at a low concentration of 60 mg/kg. Therefore, the S. quelpaertensis leaf fermentation product can be very useful as a functional ingredient for enhancing immunity.
- Subjects :
- 0301 basic medicine
Fermentation industries. Beverages. Alcohol
Sasa quelpaertensis
Plant Science
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Nitric oxide
03 medical and health sciences
Ingredient
chemistry.chemical_compound
Food science
Mycelium
Glucan
chemistry.chemical_classification
TP500-660
Mushroom
030102 biochemistry & molecular biology
biology
Hericium erinaceum
fungi
Phellinus linteus
food and beverages
biology.organism_classification
carbohydrates (lipids)
030104 developmental biology
chemistry
Fermentation
immune
Food Science
Ganoderma lucidum
Subjects
Details
- Language :
- English
- ISSN :
- 23115637
- Database :
- OpenAIRE
- Journal :
- Fermentation
- Accession number :
- edsair.doi.dedup.....dc2ac65227f5b7755ffef44e2a9be1d1
- Full Text :
- https://doi.org/10.3390/fermentation7030142