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Increased NoGo-anteriorisation in first-episode schizophrenia patients during Continuous Performance Test
- Source :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 118(12)
- Publication Year :
- 2007
-
Abstract
- Objective NoGo-stimuli during a Continuous Performance Test (CPT) activate prefrontal brain structures such as the anterior cingulate gyrus and lead to an anteriorisation of the positive electrical field of the NoGo-P300 relative to the Go-P300, so-called NoGo-anteriorisation (NGA). NGA during CPT is regarded as a neurophysiological standard index for cognitive response control. While it is known that patients with chronic schizophrenia exhibit a significant reduction in NGA, it is unclear whether this also occurs in patients undergoing their first-episode. Thus, the aim of the present study was to determine NGA in a group of patients with first-episode schizophrenia by utilizing a CPT paradigm. Methods Eighteen patients with first-episode schizophrenia and 18 matched healthy subjects were investigated electrophysiologically during a cued CPT, and the parameters of the Go- and NoGo-P300 were determined using microstate analysis. Low resolution tomography analysis (LORETA) was used for source determination. Results Due to a more posterior Go- and a more anterior NoGo-centroid, NGA was greater in patients than in healthy controls. LORETA indicated the same sources for both groups after Go-stimuli, but a more anterior source in patients after NoGo-stimuli. In patients P300-amplitude responses to both Go- and NoGo-stimuli were decreased, and P300-latency to NoGo-stimuli was increased. After the Go-stimuli false reactions and reaction times were increased in patients. Conclusions Attention was reduced in patients with first-episode schizophrenia, as indicated by more false reactions, prolongation of reaction time, P300-latencies and by a decrease in P300-amplitude. Significantly however, the NGA and prefrontal LORETA-sources indicate intact prefrontal brain structures in first-episode schizophrenia patients. Previously described changes in this indicator of prefrontal function may be related to a progressive decay in chronic schizophrenia. Significance The results support the idea of a possible new biological marker of first episode psychosis, which may be a useful parameter for the longitudinal measurement of changing prefrontal brain function in a single schizophrenia patient.
- Subjects :
- Adult
Male
Psychosis
medicine.medical_specialty
Central nervous system
Prefrontal Cortex
Audiology
Neuropsychological Tests
Gyrus Cinguli
Text mining
Cognition
Mental Processes
Predictive Value of Tests
Physiology (medical)
mental disorders
medicine
Reaction Time
Humans
Evoked potential
Tomography
Cued speech
Brain Mapping
business.industry
Electroencephalography
Neurophysiology
medicine.disease
Event-Related Potentials, P300
Sensory Systems
Electrophysiology
medicine.anatomical_structure
Neurology
Schizophrenia
Female
Schizophrenic Psychology
Neurology (clinical)
Psychology
business
Cognition Disorders
Neuroscience
Biomarkers
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 118
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....dc27c75f1ac35e3f07801afd9e9625f6