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Increased Expression of VEGF, COX-2, and Ki-67 in Barrett’s Esophagus: Does the Length Matter?
- Source :
- Digestive Diseases and Sciences. 57:1190-1196
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Barrett’s esophagus (BE) is a major complication of gastroesophageal reflux disease due to its neoplastic potential. The length of the metaplastic epithelium has been associated with cancer risk. Angiogenesis, inflammation, and increased cell proliferation are early events in the malignant sequence. Vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) and Ki-67 are indirect markers of these complex mechanisms. To examine the expression of VEGF, COX-2 and Ki-67 in BE and investigate whether there is an association to Barrett’s length. Immunohistochemistry for VEGF, COX-2, and Ki-67 was performed in well-characterized Barrett’s samples, evaluated using a qualitative scale and compared between long (LSBE) and short (SSBE) segments. The study population consisted of 98 patients (78 men). LSBE and SSBE was diagnosed in 33 (33.7%) and 65 (66.3%) cases, respectively. VEGF was expressed in vascular endothelium of all Barrett’s specimens. COX-2 and Ki-67 expression in metaplastic epithelia was strong in 81.6 and 61.2% of the samples, respectively. Ki-67 expression was significantly stronger in LSBE (p = 0.035), whereas VEGF expression was significantly increased in SSBE (p = 0.031). COX-2 expression was not associated with Barrett’s length. VEGF, COX-2, and Ki-67 were overexpressed in the majority of Barrett’s samples. The length was inversely associated with VEGF expression and directly associated with Ki-67 expression.
- Subjects :
- Adult
Male
Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Esophageal Neoplasms
Physiology
Angiogenesis
Gastroenterology
Neovascularization
Barrett Esophagus
chemistry.chemical_compound
Esophagus
Risk Factors
Internal medicine
medicine
Humans
Early Detection of Cancer
Aged
Cell Proliferation
Inflammation
Neovascularization, Pathologic
biology
business.industry
Middle Aged
medicine.disease
Immunohistochemistry
Epithelium
Gene Expression Regulation, Neoplastic
Vascular endothelial growth factor
Cell Transformation, Neoplastic
Ki-67 Antigen
medicine.anatomical_structure
chemistry
Cyclooxygenase 2
Ki-67
Barrett's esophagus
biology.protein
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....dc0cd70dcf85e8df51b973fd79dc223e