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Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease
- Source :
- Food & Function. 12:7749-7761
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects 50 million people worldwide. The current medicines have modest benefits in preventing or curing AD. Thus, it is urgent to discover drugs with the potential to change the progression of the disease. The primary clinical symptoms are memory loss and anxiety, while the critical pathological characteristics are Aβ plaques and hyperphosphorylated tau tangles. In this study, isobavachalcone (ISO), isolated from Psoralea corylifolia, was administered to 3×Tg-AD mice. It has been shown that this compound could significantly improve anxiety, memory and recognition deficits in the AD mice, attenuate the accumulation of Aβ oligomers, reduce the hyperphosphorylation of tau, and prevent the production of tau filaments. The metabolomic analysis implicates that the most probable pathways affected by ISO were bile secretion, tyrosine metabolism, and purine metabolism. In summary, ISO possesses the potential for further development as a drug candidate for AD.
- Subjects :
- 0301 basic medicine
Genetically modified mouse
Hyperphosphorylation
Mice, Transgenic
tau Proteins
Disease
Pharmacology
Psoralea
Mice
03 medical and health sciences
Chalcones
Cognition
0302 clinical medicine
Alzheimer Disease
Animals
Humans
Medicine
Cognitive Dysfunction
Phosphorylation
Purine metabolism
Pathological
Memory Disorders
Amyloid beta-Peptides
business.industry
General Medicine
Progressive neurodegenerative disorder
030104 developmental biology
Anxiety
medicine.symptom
business
030217 neurology & neurosurgery
Drugs, Chinese Herbal
Food Science
Subjects
Details
- ISSN :
- 2042650X and 20426496
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Food & Function
- Accession number :
- edsair.doi.dedup.....dc048790b25fc84b79225da0ee8b0c52