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Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current
- Source :
- Circulation research. 79(4)
- Publication Year :
- 1996
-
Abstract
- The expression of 15 different K + channels in canine heart was examined, and a new K + channel gene (Kv4.3), which encodes a rapidly inactivating K + current, is described. The Kv4.3 channel was found to have biophysical and pharmacological properties similar to the native canine transient outward current (I to ). The Kv4.3 gene is also expressed in human and rat heart. It is concluded that the Kv4.3 channel underlies the bulk of the I to in canine ventricular myocytes, and probably in human myocytes. Both the Kv4.3 and Kv4.2 channels are likely to contribute to the I to in rat heart, and differential expression of these two channels can account for observed differences in the kinetic properties of the I to in different regions of rat ventricle. There are significant differences in the pattern of K + channel expression in canine heart, compared with rat heart, and these differences may be an adaptation to the different requirements for cardiac function in mammals of markedly different sizes. It is possible that the much longer ventricular action potential duration observed in canine heart compared with rat heart is due, in part, to the lower levels of Kv1.2, Kv2.1, and Kv4.2 gene expression in canine heart.
- Subjects :
- medicine.medical_specialty
Potassium Channels
Physiology
Heart Ventricles
Molecular Sequence Data
Biology
Ventricular action potential
Dogs
Internal medicine
medicine
Myocyte
Animals
Humans
Amino Acid Sequence
Cloning, Molecular
Cells, Cultured
Cardiac transient outward potassium current
Ion Transport
Voltage-gated ion channel
Cardiac muscle
Potassium channel
Cell biology
Rats
Electrophysiology
medicine.anatomical_structure
Endocrinology
Shal Potassium Channels
Ventricle
Potassium Channels, Voltage-Gated
cardiovascular system
Cardiology and Cardiovascular Medicine
Sequence Alignment
Sequence Analysis
Subjects
Details
- ISSN :
- 00097330
- Volume :
- 79
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Circulation research
- Accession number :
- edsair.doi.dedup.....dbfb3678478f04a48e5c98e045b3910a