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Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis

Authors :
Soon Chul Heo
Il Ho Jang
Jae Ho Kim
Yang Woo Kwon
Eun Jung Choi
Source :
Advances in biological regulation. 57
Publication Year :
2014

Abstract

Endothelial progenitor cells (EPCs) hold a great promise as a therapeutic mediator in treatment of ischemic disease conditions. The discovery of EPCs in adult blood has been a cause of significant enthusiasm in the field of endothelial cell research and numerous clinical trials have been expedited. After more than a decade of research in basic science and clinical applications, limitations and new strategies of EPC therapeutics have emerged. With various phenotypes, vague definitions, and uncertain distinction from hematopoietic cells, understanding EPC biology remains challenging. However, EPCs, still hold great hope for treatment of critical ischemic injury as low concern regarding safety can accelerate the clinical applications from basic findings. This review provides an introduction to EPC as cellular therapeutics, which highlights a recent finding that EPC homing was promoted through FPR2 signaling.

Details

ISSN :
22124934
Volume :
57
Database :
OpenAIRE
Journal :
Advances in biological regulation
Accession number :
edsair.doi.dedup.....dbfa36716bec8bba503441d17216005c