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Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis
- Source :
- Advances in biological regulation. 57
- Publication Year :
- 2014
-
Abstract
- Endothelial progenitor cells (EPCs) hold a great promise as a therapeutic mediator in treatment of ischemic disease conditions. The discovery of EPCs in adult blood has been a cause of significant enthusiasm in the field of endothelial cell research and numerous clinical trials have been expedited. After more than a decade of research in basic science and clinical applications, limitations and new strategies of EPC therapeutics have emerged. With various phenotypes, vague definitions, and uncertain distinction from hematopoietic cells, understanding EPC biology remains challenging. However, EPCs, still hold great hope for treatment of critical ischemic injury as low concern regarding safety can accelerate the clinical applications from basic findings. This review provides an introduction to EPC as cellular therapeutics, which highlights a recent finding that EPC homing was promoted through FPR2 signaling.
- Subjects :
- Cancer Research
Angiogenesis
Neovascularization, Physiologic
Biology
Bioinformatics
Formyl peptide receptor 2
Mediator
Ischemia
Genetics
Humans
Therapeutic angiogenesis
Progenitor cell
Receptors, Lipoxin
Molecular Biology
Endothelial Cells
Receptors, Formyl Peptide
Endothelial stem cell
Haematopoiesis
Adult Stem Cells
embryonic structures
Immunology
cardiovascular system
Molecular Medicine
circulatory and respiratory physiology
Homing (hematopoietic)
Signal Transduction
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 22124934
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Advances in biological regulation
- Accession number :
- edsair.doi.dedup.....dbfa36716bec8bba503441d17216005c