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Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages
- Source :
- Microbial Pathogenesis. 40:171-176
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- We aimed to reveal the regulatory function of macrophage scavenger receptor-A (MSR-A) in proinflammatory cytokine production by macrophages stimulated with mycobacterial cord factor (CF). By the culture with CF, MSR-A (+/+) alveolar macrophages and Kupffer cells produced TNF-alpha/MIP-1alpha in a time- and dose-dependent manner. However, the amounts of cytokines produced by them were much less compared to those produced by MSR-A (-/-) macrophages. Consistent with this, treatment of MSR-A (+/+) macrophages with anti-MSR-A antibody increased TNF-alpha production. Binding of CF to MSR-A was demonstrated by measuring the binding affinity. These results indicate that CF binds MSR-A, and MSR-A down-regulates TNF-alpha/MIP-1alpha production by activated macrophages, suggesting the role of this receptor in suppression of excessive inflammatory responses during mycobacterial infection.
- Subjects :
- Kupffer Cells
medicine.medical_treatment
Down-Regulation
Biology
Microbiology
Proinflammatory cytokine
Mice
Macrophages, Alveolar
medicine
Animals
Macrophage
Scavenger receptor
Chemokine CCL4
Cord factor
Tumor Necrosis Factor-alpha
Kupffer cell
Scavenger Receptors, Class A
Mycobacterium tuberculosis
Macrophage Activation
Macrophage Inflammatory Proteins
Molecular biology
Infectious Diseases
medicine.anatomical_structure
Cytokine
Immunology
Alveolar macrophage
Cord Factors
Cytokines
Tumor necrosis factor alpha
Subjects
Details
- ISSN :
- 08824010
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Microbial Pathogenesis
- Accession number :
- edsair.doi.dedup.....dbebd17da656648374893eec3a49d314