Clinical relevance of anti-platelet antibodies and the hepatic clearance of platelets in patients with immune thrombocytopenia (ITP)

To the editor: Immune thrombocytopenia (ITP) is an autoimmune disorder whose primary pathogenesis is mediated by Fc receptor (FcR) clearance of antibody-opsonized platelets by spleen macrophages.[1][1] Recently, however, an Fc-independent mechanism of platelet clearance mediated by antibodies