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Brain aconitase activity is not decreased in progressive supranuclear palsy
- Source :
- Neurology. 59(1)
- Publication Year :
- 2002
-
Abstract
- The novel finding of decreased activity of aconitase, a key Krebs cycle enzyme highly sensitive to oxidative damage, in cybrid cell lines using mitochondrial DNA from patients with progressive supranuclear palsy (PSP) implies an enzyme abnormality in brain. However, the authors found that postmortem brain aconitase activity is normal in PSP. This suggests that patients with PSP do not have systemic aconitase deficiency and that data derived from cybrid cell models of neurodegenerative disorders might not always predict similar changes in human brain.
- Subjects :
- Aconitate Hydratase
medicine.medical_specialty
Central nervous system
Brain
Supranuclear ophthalmoplegia
Human brain
Biology
Multiple System Atrophy
medicine.disease
Aconitase
eye diseases
Progressive supranuclear palsy
Central nervous system disease
Citric acid cycle
medicine.anatomical_structure
Degenerative disease
Endocrinology
Internal medicine
medicine
Humans
Neurology (clinical)
Supranuclear Palsy, Progressive
Aged
Subjects
Details
- ISSN :
- 00283878
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....dbb8c8b4b9b650b6897a3bac9a40e450