Back to Search
Start Over
Comparison between closed pleural biopsy and medical thoracoscopy for the diagnosis of undiagnosed exudative pleural effusions: a systematic review and meta-analysis
- Source :
- Transl Lung Cancer Res
- Publication Year :
- 2020
- Publisher :
- AME Publishing Company, 2020.
-
Abstract
- BACKGROUND: Exudative pleural effusion (EPE) is a common diagnostic challenge. The utility of medical thoracoscopy (MT) and closed pleural biopsy (CPB) to aid in the diagnosis of EPE has been reported in many published studies. Herein, we perform a systematic review and meta-analysis to compare the diagnostic yield and safety of CPB and MT in EPE. METHODS: Four databases were searched for studies reporting the diagnostic yield of CPB and MT for EPE. The quality of the included studies was evaluated according to the quality assessment of diagnostic accuracy studies (QUADAS) tool. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and complication risks were compared between the two groups. RESULTS: Ten studies dealing with CPB and twenty-three studies dealing with MT for the diagnosis of EPE were included in this meta-analysis. Pooled sensitivity, specificity, PLR, NLR and DOR of CPB group was 77%, 99%, 32.55, 0.22, 165.71, respectively, while pooled sensitivity, specificity, PLR, NLR and DOR of MT group was 93%, 100%, 10.82, 0.08, 162.81, respectively. The area under the summary receiver operating characteristic (SROC) curve of CPB and MT were both 0.97. The ability of CPB to diagnose non-malignant diseases was like MT (69% vs. 68%), while the ability was lower than that of MT to diagnose malignant diseases (72% vs. 92%). The pooled diagnostic accuracy of CPB and MT for mesothelioma was 26% (95% CI, 14–38%) and 42% (95% CI, 22–62%) (P
- Subjects :
- medicine.medical_specialty
Receiver operating characteristic
medicine.diagnostic_test
business.industry
030204 cardiovascular system & hematology
medicine.disease
Likelihood ratios in diagnostic testing
Gastroenterology
Exudative pleural effusion
03 medical and health sciences
0302 clinical medicine
surgical procedures, operative
030228 respiratory system
Oncology
Meta-analysis
Internal medicine
Diagnostic odds ratio
Thoracoscopy
Medicine
Original Article
Mesothelioma
business
Complication
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Transl Lung Cancer Res
- Accession number :
- edsair.doi.dedup.....dba9bf09c02be41036f7d89961efb521