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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax
- Source :
- Case Reports in Hematology, Case Reports in Hematology, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Myelodysplastic syndromes are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow. They are a group of heterogeneous clonal stem cell malignancies with a high risk to progress to acute myeloid leukemia. Currently, there are no curative FDA-approved medications for myelodysplastic syndromes. Hematopoietic cell transplantation is potentially the only curative option; however, treatment is often unavailable due to age and comorbidities. Hypomethylating agents, azacitidine and decitabine, and the immunomodulatory agent, lenalidomide, are the only FDA approved medications for the treatment of MDS, all of which are noncurative. Venetoclax, an inhibitor of the antiapoptotic protein BCL-2 used to treat chronic lymphocytic leukemia, is currently being evaluated in clinical trials as a monotherapy in high-risk myelodysplastic syndromes/acute myeloid leukemia. We present a patient with transfusion-dependent myelodysplastic syndromes refractory to the current standard of care treatment not a candidate for hematopoietic cell transplantation who responded well to monotherapy treatment with venetoclax and has since remained transfusion-independent.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Chronic lymphocytic leukemia
Azacitidine
Decitabine
Case Report
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Diseases of the blood and blood-forming organs
Lenalidomide
Venetoclax
business.industry
Myelodysplastic syndromes
Myeloid leukemia
General Medicine
medicine.disease
Transplantation
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
RC633-647.5
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20906579 and 20906560
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Case Reports in Hematology
- Accession number :
- edsair.doi.dedup.....dba6f377001779f8c90e825be3394c54