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Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR)
- Source :
- European heart journal. 42(45)
- Publication Year :
- 2021
-
Abstract
- Aims A fractional flow reserve (FFR) value ≥0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an investigator-initiated, single-centre, randomized controlled trial to determine the feasibility and efficacy of a post-PCI FFR-guided optimization strategy vs. standard coronary angiography in achieving final post-PCI FFR values ≥0.90. Methods and results After angiographically guided PCI, patients were randomized 1:1 to receive a physiology-guided incremental optimization strategy (PIOS) or a blinded coronary physiology assessment (control group). The primary outcome was the proportion of patients with a final post-PCI FFR ≥0.90. Final FFR ≤0.80 was a prioritized secondary outcome. A total of 260 patients were randomized (131 to PIOS, 129 to control) and 68.1% of patients had an initial post-PCI FFR Conclusion Over two-thirds of patients had a physiologically suboptimal result after angiography-guided PCI. An FFR-guided optimization strategy did not significantly increase the proportion of patients with a final FFR ≥0.90, but did reduce the proportion of patients with a final FFR ≤0.80.
- Subjects :
- Coronary angiography
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Fractional flow reserve
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
law.invention
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Randomized controlled trial
law
Internal medicine
medicine
Clinical endpoint
Humans
030212 general & internal medicine
business.industry
Percutaneous coronary intervention
Stent
Confidence interval
Fractional Flow Reserve, Myocardial
Treatment Outcome
Conventional PCI
Cardiology
Stents
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15229645 and 0195668X
- Volume :
- 42
- Issue :
- 45
- Database :
- OpenAIRE
- Journal :
- European heart journal
- Accession number :
- edsair.doi.dedup.....dba69bce877fbe6aa438095ca3c02f5b