Back to Search
Start Over
Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi
- Source :
- Journal of Antimicrobial Chemotherapy
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- BackgroundAntimicrobial therapy is essential for the treatment of enteric fever, the infection caused by Salmonella serovars Typhi and Paratyphi A. However, an increase in resistance to key antimicrobials and the emergence of MDR and XDR in Salmonella Typhi poses a major threat for efficacious outpatient treatments.ObjectivesWe recently identified tebipenem, an oral carbapenem licensed for use for respiratory tract infections in Japan, as a potential alternative treatment for MDR/XDR Shigella spp. Here, we aimed to test the in vitro antibacterial efficacy of this drug against MDR and XDR typhoidal Salmonella.MethodsWe determined the in vitro activity of tebipenem in time–kill assays against a collection of non-XDR and XDR Salmonella Typhi and Salmonella Paratyphi A (non-XDR) isolated in Nepal and Bangladesh. We also tested the efficacy of tebipenem in combination with other antimicrobials.ResultsWe found that both XDR and non-XDR Salmonella Typhi and Salmonella Paratyphi A are susceptible to tebipenem, exhibiting low MICs, and were killed within 8–24 h at 2–4×MIC. Additionally, tebipenem demonstrated synergy with two other antimicrobials and could efficiently induce bacterial killing.ConclusionsSalmonella Paratyphi A and XDR Salmonella Typhi display in vitro susceptibility to the oral carbapenem tebipenem, while synergistic activity with other antimicrobials may limit the emergence of resistance. The broad-spectrum activity of this drug against MDR/XDR organisms renders tebipenem a good candidate for clinical trials.
- Subjects :
- Microbiology (medical)
Carbapenem
Salmonella
Tebipenem
Salmonella typhi
medicine.disease_cause
complex mixtures
Typhoid fever
Microbiology
chemistry.chemical_compound
medicine
AcademicSubjects/MED00740
Humans
Pharmacology (medical)
Shigella
Typhoid Fever
Original Research
Pharmacology
business.industry
Salmonella paratyphi A
Antimicrobial
medicine.disease
Anti-Bacterial Agents
Infectious Diseases
AcademicSubjects/MED00290
chemistry
Carbapenems
bacteria
business
AcademicSubjects/MED00230
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14602091 and 03057453
- Volume :
- 76
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Antimicrobial Chemotherapy
- Accession number :
- edsair.doi.dedup.....dba4e931d0b446b9710a66e808615c9b