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Structural Insights into PROTAC-Mediated Degradation of Bcl-xL
- Source :
- ACS chemical biology. 15(9)
- Publication Year :
- 2020
-
Abstract
- The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival. Structural studies of Bcl-xL formed the foundation for the development of the first Bcl-2 family inhibitors and FDA approved drugs. Recently
- Subjects :
- 0301 basic medicine
bcl-X Protein
Bcl-xL
Plasma protein binding
Crystallography, X-Ray
01 natural sciences
Biochemistry
03 medical and health sciences
Cell Line, Tumor
Humans
Benzothiazoles
biology
010405 organic chemistry
Chemistry
General Medicine
Isoquinolines
0104 chemical sciences
Cell biology
030104 developmental biology
Cell culture
Von Hippel-Lindau Tumor Suppressor Protein
Cancer cell
Proteolysis
biology.protein
Molecular Medicine
Oligopeptides
Protein Binding
Subjects
Details
- ISSN :
- 15548937
- Volume :
- 15
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- ACS chemical biology
- Accession number :
- edsair.doi.dedup.....db9fcaed9e9c6a30480d548bb31683e0