Back to Search
Start Over
Ten-year resistance trends in pathogens causing healthcare-associated infections; reflection of infection control interventions at a multi-hospital healthcare system in Saudi Arabia, 2007–2016
- Source :
- Antimicrobial Resistance and Infection Control, Vol 9, Iss 1, Pp 1-12 (2020), Antimicrobial Resistance and Infection Control
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background Studying temporal changes in resistant pathogens causing healthcare-associated infections (HAIs) is crucial in improving local antimicrobial and infection control practices. The objective was to describe ten-year trends of resistance in pathogens causing HAIs in a tertiary care setting in Saudi Arabia and to compare such trends with those of US National Health Surveillance Network (NHSN). Methods Pooled analysis of surveillance data that were prospectively collected between 2007 and 2016 in four hospitals of Ministry of National Guard Health Affairs. Definitions and methodology of HAIs and antimicrobial resistance were based on NHSN. Consecutive NHSN reports were used for comparisons. Results A total 1544 pathogens causing 1531 HAI events were included. Gram negative pathogens (GNP) were responsible for 63% of HAIs, with a significant increasing trend in Klebsiella spp. and a decreasing trend in Acinetobacter. Methicillin-resistant Staphylococcus aureus (27.0%) was consistently less frequent than NHSN. Vancomycin-resistant Enterococci (VRE, 20.3%) were more than doubled during the study, closing the gap with NHSN. Carbapenem resistance was highest with Acinetobacter (68.3%) and Pseudomonas (36.8%). Increasing trends of carbapenem resistance were highest in Pseudomonas and Enterobacteriaceae, closing initial gaps with NHSN. With the exception of Klebsiella and Enterobacter, multidrug-resistant (MDR) GNPs were generally decreasing, mainly due to the decreasing resistance towards cephalosporins, fluoroquinolones, and aminoglycosides. Conclusion The findings showed increasing trends of carbapenem resistance and VRE, which may reflect heavy use of carbapenems and vancomycin. These findings may highlight the need for effective antimicrobial stewardship programs, including monitoring and feedback on antimicrobial use and resistance.
- Subjects :
- 0301 basic medicine
Drug resistance
Multidrug resistance
Antimicrobial resistance
0302 clinical medicine
Drug Resistance, Multiple, Bacterial
Klebsiella
Prevalence
Antimicrobial stewardship
Medicine
Infection control
Pharmacology (medical)
Prospective Studies
030212 general & internal medicine
Cross Infection
Surveillance
Acinetobacter
biology
Antimicrobial
Hospitals
Anti-Bacterial Agents
Infectious Diseases
Vancomycin
medicine.drug
Methicillin-Resistant Staphylococcus aureus
Microbiology (medical)
030106 microbiology
Saudi Arabia
Temporal trends
Healthcare-associated infections
lcsh:Infectious and parasitic diseases
Hospital
03 medical and health sciences
Antibiotic resistance
Pseudomonas
Environmental health
Drug Resistance, Bacterial
Humans
lcsh:RC109-216
business.industry
Research
Public Health, Environmental and Occupational Health
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Multiple drug resistance
Carbapenem-Resistant Enterobacteriaceae
Carbapenems
Health Facilities
business
Delivery of Health Care
Subjects
Details
- ISSN :
- 20472994
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Resistance & Infection Control
- Accession number :
- edsair.doi.dedup.....db99ade4bb2e7af6a6bb6a437d6adced