Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector

Authors :: Ganesh N. Pandian
Takuya Hidaka
Toshikazu Bando
Yutaro Tsubono
Hiroshi Sugiyama
Kaori Hashiya
Source :: Chemical communications (Cambridge, England). 56(82)
Publication Year :: 2020
Abstract: The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole–imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and HER2 transcription in live cells. This simple vector expands the application of long PIPs in live cells by overcoming the compound delivery problems associated with them.

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