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Total Urinary Arsenic and Inorganic Arsenic Concentrations and Birth Outcomes in Pregnant Women of Tacna, Peru: A Cross-Sectional Study
- Source :
- Exposure and Health
- Publication Year :
- 2020
- Publisher :
- Springer, 2020.
-
Abstract
- Inorganic arsenic exposure has been linked to the development of several health conditions, including adverse birth outcomes, and around 150 million of people worldwide are exposed to levels above the WHO suggested limit of 10 μg/L. A recent risk assessment in pregnant women of Tacna, of this same population performed by our group, found that 70.25% were exposed to arsenic concentrations in drinking water ≥ 25 μg/L. The present study aimed to evaluate the relationship between prenatal total urinary arsenic (U-tAs) and inorganic arsenic (U-iAs) with adverse birth outcomes. A total of 147 pregnant women from the province of Tacna, Peru, during February–March, 2019, were evaluated for U-tAs and U-iAs exposure during their second trimester of pregnancy, while the birth records of their children were collected from the local hospital. The geometric mean U-tAs was 43.97 ± 25.88 μg/L (P50 22.30, range 5.99–181.94 μg/L) and U-iAs was 5.27 ± 2.91 μg/L. Controlling for maternal age, pre-pregnancy BMI, parity, mother’s education, and newborn sex, no relationship was observed between tertile of U-tAs and the birth outcomes considered, although we found an apparent but statistically non-significant dose–response relationship for small for gestational age 2.38% (95% CI 0.003, 0.16), versus 7.32% (95% CI 0.02, 0.21%), and versus 8.57% (95% CI 0.03, 0.25%). This finding requires further evaluation considering other factors such as metabolic arsenic species, additional maternal covariates, and ethnicity.
- Subjects :
- medicine.medical_specialty
purl.org/pe-repo/ocde/ford#3.03.05 [https]
Cross-sectional study
Health, Toxicology and Mutagenesis
Urinary system
Population
chemistry.chemical_element
age structure
010501 environmental sciences
Brief Communication
World Health Organization
01 natural sciences
dose-response relationship
purl.org/pe-repo/ocde/ford#5.07.01 [https]
03 medical and health sciences
0302 clinical medicine
Medicine
Birth outcomes
spatiotemporal analysis
030212 general & internal medicine
education
Arsenic
0105 earth and related environmental sciences
Water Science and Technology
Pregnancy
education.field_of_study
concentration (composition)
business.industry
Obstetrics
Public health
drinking water
public health
Urinary arsenic
Public Health, Environmental and Occupational Health
arsenic
risk assessment
medicine.disease
womens health
Pollution
Dose–response relationship
chemistry
child health
ethnicity
Arsenic exposure
pregnancy
Tacna
Risk assessment
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Exposure and Health
- Accession number :
- edsair.doi.dedup.....db8dd2abc56cb53b6e5b2d39bc80eb6c