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Clinical Updates in Primary Biliary Cholangitis: Trends, Epidemiology, Diagnostics, and New Therapeutic Approaches
- Source :
- Journal of Clinical and Translational Hepatology
- Publication Year :
- 2019
-
Abstract
- Primary biliary cholangitis, formerly known as primary biliary cirrhosis, is a chronic, autoimmune, and cholestatic disease ameliorating the biliary epithelial system causing fibrosis and end-stage liver disease, over time. Patients range from an asymptomatic phase early in the disease course, to symptoms of decompensated cirrhosis later in its course. This review focuses on the current consensus on the epidemiology, diagnosis, and management of patients with primary biliary cholangitis. We also discuss established medical management as well as novel and investigational therapeutics in the pipeline for management of PBC.
- Subjects :
- medicine.medical_specialty
Epidemiology
Disease
Review Article
Asymptomatic
Disease course
UDCA
03 medical and health sciences
Liver disease
chemistry.chemical_compound
0302 clinical medicine
Primary biliary cirrhosis
Fibrosis
Primary biliary cholangitis (PBC)
medicine
Intensive care medicine
Hepatology
business.industry
Obeticholic acid
medicine.disease
Treatment
chemistry
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
medicine.symptom
business
Subjects
Details
- ISSN :
- 22250719
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of clinical and translational hepatology
- Accession number :
- edsair.doi.dedup.....db6d83adc13860007fafee6ea314d57e