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Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease
- Source :
- Nyilas, Sylvia Meryl; Bauman, G.; Sommer, G.; Stranzinger, Enno; Pusterla, O.; Frey, U.; Korten, Insa Christina Severine; Singer, Florian; Casaulta Aebischer, Carmen; Bieri, O.; Latzin, Philipp (June 2017). Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease (Unpublished). In: SCR Schweizer Radiologie Kongress. Bern.
- Publication Year :
- 2017
- Publisher :
- European Respiratory Society, 2017.
-
Abstract
- Lung function tests are commonly used to monitor lung disease in cystic fibrosis (CF). While practical, they cannot locate the exact origin of functional impairment. Contemporary magnetic resonance imaging (MRI) techniques provide information on the location of disease but the need for contrast agents constrains their repeated application. We examined the correlation between functional MRI, performed without administration of contrast agent, and lung clearance index (LCI) from nitrogen multiple-breath washout (N2-MBW).40 children with CF (median (range) age 12.0 (6–18) years) and 12 healthy age-matched controls underwent functional and structural MRI and lung function tests on the same day. Functional MRI provided semiquantitative measures of perfusion (RQ) and ventilation (RFV) impairment as percentages of affected lung volume. Morphological MRI was evaluated using CF-specific scores. LCI measured global ventilation inhomogeneity.MRI detected functional impairment in CF:RFV19–38% andRQ16–35%.RFVandRQcorrelated strongly with LCI (r=0.76, pNoninvasive functional MRI is a promising method to detect and visualise perfusion and ventilation impairment in CF without the need for contrast agents.
- Subjects :
- Pulmonary and Respiratory Medicine
Spirometry
Male
Adolescent
Cystic Fibrosis
610 Medicine & health
Lung Clearance Index
Cystic fibrosis
030218 nuclear medicine & medical imaging
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
Forced Expiratory Volume
medicine
Tidal Volume
Humans
Lung volumes
Prospective Studies
Child
Lung
Tidal volume
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Plethysmography
Cross-Sectional Studies
030228 respiratory system
Case-Control Studies
Breathing
Female
Nuclear medicine
business
Switzerland
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nyilas, Sylvia Meryl; Bauman, G.; Sommer, G.; Stranzinger, Enno; Pusterla, O.; Frey, U.; Korten, Insa Christina Severine; Singer, Florian; Casaulta Aebischer, Carmen; Bieri, O.; Latzin, Philipp (June 2017). Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease (Unpublished). In: SCR Schweizer Radiologie Kongress. Bern.
- Accession number :
- edsair.doi.dedup.....db6a0e49a70946d4ed5d86826226563b
- Full Text :
- https://doi.org/10.7892/boris.107777