Back to Search
Start Over
Wnt signaling: physiology and pathology
- Source :
- Growth factors (Chur, Switzerland). 22(3)
- Publication Year :
- 2004
-
Abstract
- Signaling by the Wnt family of secreted glycoproteins has been demonstrated to be essential both in normal embryonic development and in the pathogenesis of a variety of diseases, including cancer. This signaling pathway is exquisitely regulated by a large and complex array of proteins, which act as agonists or antagonists of signal transduction, modulating the Wnt signal extracellularly, in the cytoplasm and in the nucleus. Here, we will briefly review the canonical Wnt signaling pathway and consider molecular defects in Wnt signaling components known to promote uncontrolled cell growth following induction of Wnt signaling. We will also focus on two recently identified factors in this pathway, that seem to act as Wnt signaling antagonists, one functioning in the cytoplasm called Disabled-2 and the other in the nucleus named Chibby.
- Subjects :
- Transcriptional Activation
Frizzled
Cytoplasm
Beta-catenin
Transcription, Genetic
Clinical Biochemistry
Embryonic Development
Biology
Models, Biological
Endocrinology
Axin Protein
Neoplasms
Animals
Humans
Genes, Tumor Suppressor
Autocrine signalling
beta Catenin
Adaptor Proteins, Signal Transducing
Cell Proliferation
Glycoproteins
Cell Nucleus
Tumor Suppressor Proteins
Wnt signaling pathway
LRP6
Signal transducing adaptor protein
Nuclear Proteins
LRP5
Cell Biology
DNA
Cell biology
Repressor Proteins
Wnt Proteins
Adaptor Proteins, Vesicular Transport
Cytoskeletal Proteins
biology.protein
Trans-Activators
Intercellular Signaling Peptides and Proteins
Signal transduction
Apoptosis Regulatory Proteins
Carrier Proteins
Signal Transduction
Subjects
Details
- ISSN :
- 08977194
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Growth factors (Chur, Switzerland)
- Accession number :
- edsair.doi.dedup.....db60734fc8869fd10fbcab40f25467c0