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A Novel 18-Marker Panel Predicting Clinical Outcome in Breast Cancer
- Source :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 26(11)
- Publication Year :
- 2017
-
Abstract
- Background: Gene expression profiling has made considerable contributions to our understanding of cancer biology and clinical care. This study describes a novel gene expression signature for breast cancer–specific survival that was validated using external datasets. Methods: Gene expression signatures for invasive breast carcinomas (mainly luminal B subtype) corresponding to 136 patients were analyzed using Cox regression, and the effect of each gene on disease-specific survival (DSS) was estimated. Iterative Bayesian model averaging was applied on multivariable Cox regression models resulting in an 18-marker panel, which was validated using three external validation datasets. The 18 genes were analyzed for common pathways and functions using the Ingenuity Pathway Analysis software. This study complied with the REMARK criteria. Results: The 18-gene multivariable model showed a high predictive power for DSS in the training and validation cohort and a clear stratification between high- and low-risk patients. The differentially expressed genes were predominantly involved in biological processes such as cell cycle, DNA replication, recombination, and repair. Furthermore, the majority of the 18 genes were found to play a pivotal role in cancer. Conclusions: Our findings demonstrated that the 18 molecular markers were strong predictors of breast cancer–specific mortality. The stable time-dependent area under the ROC curve function (AUC(t)) and high C-indices in the training and validation cohorts were further improved by fitting a combined model consisting of the 18-marker panel and established clinical markers. Impact: Our work supports the applicability of this 18-marker panel to improve clinical outcome prediction for breast cancer patients. Cancer Epidemiol Biomarkers Prev; 26(11); 1619–28. ©2017 AACR.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Pathology
Epidemiology
Breast Neoplasms
Kaplan-Meier Estimate
03 medical and health sciences
Bayes' theorem
0302 clinical medicine
Breast cancer
Predictive Value of Tests
Internal medicine
Carcinoma
Biomarkers, Tumor
Medicine
Humans
Genetic Testing
Gene
Oligonucleotide Array Sequence Analysis
Proportional Hazards Models
business.industry
Proportional hazards model
Gene Expression Profiling
Carcinoma, Ductal, Breast
Cancer
Bayes Theorem
medicine.disease
Prognosis
Gene expression profiling
030104 developmental biology
ROC Curve
030220 oncology & carcinogenesis
Predictive value of tests
Female
business
Transcriptome
Subjects
Details
- ISSN :
- 15387755
- Volume :
- 26
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Accession number :
- edsair.doi.dedup.....db581c7da32b7a74e715ea31e520c237