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Inflammatory markers and treatment outcome in treatment resistant depression: A systematic review
- Source :
- Journal of Affective Disorders. 257:640-649
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background A substantial percentage of depressed patients do not respond satisfactorily to conventional antidepressant treatment. This treatment resistant depression (TRD) may be partly related to inflammatory processes in the central nervous system. Accordingly, peripheral inflammatory markers might serve to predict treatment response with novel but still experimental forms of antidepressant treatment. Methods A literature search on treatment of TRD and inflammatory markers was performed using the PubMed/Medline database on November 8th 2018, and 95 articles were retrieved initially, which were subsequently screened and selected only when the inclusion and exclusion criteria were met. Results Ten studies were recruited. In five studies higher baseline interleukin-6 (IL-6) or C-reactive protein (CRP)/high-sensitivity-CRP (hsCRP) in blood predicted better response to medication with anti-inflammatory characteristics, such as ketamine and infliximab. One study found that higher IL-6 predicted worse response to antidepressant treatment in patients with TRD. No evidence was found for the predictive value of other inflammatory markers (e.g., Tumor Necrosis Factor-α, Interferon-γ). Limitations The number of available studies was limited; included studies showed considerable methodological variation and used different definitions for TRD. Conclusion The inflammatory markers IL-6 and CRP/hsCRP could hold promise as markers for the prediction of treatment response in TRD. Clearly, this field of research is still far from mature but it could pave the way for novel and efficacious treatments for at least the inflammatory type of TRD with more well-designed studies and more convincing results.
- Subjects :
- Male
LIPOPOLYSACCHARIDE
THERAPY
Depressive Disorder, Treatment-Resistant
0302 clinical medicine
SCHIZOPHRENIA
Medicine
OXIDATIVE STRESS
biology
BIPOLAR DISORDER
Middle Aged
Antidepressive Agents
Psychiatry and Mental health
Clinical Psychology
C-Reactive Protein
Treatment Outcome
Schizophrenia
Inclusion and exclusion criteria
Antidepressant
Female
Ketamine
Inflammation Mediators
medicine.symptom
medicine.drug
Adult
medicine.medical_specialty
Inflammation
Treatment resistant depression
Interferon-gamma
03 medical and health sciences
Internal medicine
Humans
Bipolar disorder
TREATMENT RESPONSE
IL-6
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
CYTOKINES
C-reactive protein
medicine.disease
Infliximab
030227 psychiatry
biology.protein
Inflammatory marker
Prediction
business
Treatment-resistant depression
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 257
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....db48fbf11a79d6fbe47a816dc1f65ee1