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Role of Chemokines in the Pathogenesis of Acute Lung Injury
- Source :
- American Journal of Respiratory Cell and Molecular Biology. 46:566-572
- Publication Year :
- 2012
- Publisher :
- American Thoracic Society, 2012.
-
Abstract
- Acute lung injury (ALI) is due to an uncontrolled systemic inflammatory response resulting from direct injury to the lung or indirect injury in the setting of a systemic process. Such insults lead to the systemic inflammatory response syndrome (SIRS), which includes activation of leukocytes—alveolar macrophages and sequestered neutrophils—in the lung. Although systemic inflammatory response syndrome is a physiologic response to an insult, systemic leukocyte activation, if excessive, can lead to end organ injury, such as ALI. Excessive recruitment of leukocytes is critical to the pathogenesis of ALI, and the magnitude and duration of the inflammatory process may ultimately determine the outcome in patients with ALI. Leukocyte recruitment is a well orchestrated process that depends on the function of chemokines and their receptors. Understanding the mechanisms that contribute to leukocyte recruitment in ALI may ultimately lead to the development of effective therapeutic strategies.
- Subjects :
- Pulmonary and Respiratory Medicine
Chemokine
Acute Lung Injury
Clinical Biochemistry
Inflammation
Lung injury
Lymphocyte Activation
Pathogenesis
medicine
Humans
In patient
Receptor
Molecular Biology
Lung
biology
business.industry
Cell Biology
Macrophage Activation
respiratory system
medicine.disease
respiratory tract diseases
Systemic inflammatory response syndrome
Translational Review
medicine.anatomical_structure
Immunology
biology.protein
Receptors, Chemokine
Chemokines
medicine.symptom
business
Subjects
Details
- ISSN :
- 15354989 and 10441549
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology
- Accession number :
- edsair.doi.dedup.....db3dbfcefb50b15302f6a9d995cc1930