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Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia
- Source :
- Annals of Hematology. 92:315-323
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Deregulation of the hematopoietic stem cell (HSC) compartment represents a hallmark of acute myeloid leukemia (AML). Recently, in vivo screening for genes that are involved in the regulation of HSCs has led to the discovery of Musashi-2 (MSI2) as a key regulator of HSCs and as a suppressor of NUMB. In order to analyze the prognostic importance of MSI2 and NUMB expression in AML, MSI2 and NUMB transcript levels from 454 AML patients treated in multicenter trials AML SHG 0199 (ClinicalTrials Identifier NCT00209833) and 0295, and 38 healthy volunteers were analyzed by reverse transcriptase PCR in the context of other molecular markers (NPM1, FLT3, CEBPA, IDH1/IDH2, DNMT3A, NRAS, WT1, KIT, MN1, BAALC, ERG, and WT1). In AML, patients with high MSI2 expression were more likely to be FLT3-ITD positive (P
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
NPM1
Myeloid
Adolescent
Nerve Tissue Proteins
Context (language use)
Biology
Young Adult
hemic and lymphatic diseases
Internal medicine
CEBPA
medicine
Humans
BAALC
Membrane Proteins
RNA-Binding Proteins
Myeloid leukemia
Hematology
General Medicine
Middle Aged
Hematopoietic Stem Cells
Prognosis
medicine.disease
Gene Expression Regulation, Neoplastic
Survival Rate
Leukemia, Myeloid, Acute
Leukemia
medicine.anatomical_structure
embryonic structures
Immunology
NUMB
Female
Nucleophosmin
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology
- Accession number :
- edsair.doi.dedup.....db2b03e8233342e4ec9dfb856d9ae4d2