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Sodium-glucose cotransporter 2 inhibitors antagonize lipotoxicity in human myeloid angiogenic cells and ADP-dependent activation in human platelets: potential relevance to prevention of cardiovascular events
- Source :
- Cardiovascular Diabetology, Cardiovascular diabetology, 19 (1, Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-15 (2020)
- Publication Year :
- 2020
- Publisher :
- BioMed Central, 2020.
-
Abstract
- The clear evidence of cardiovascular benefits in cardiovascular outcome trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in type 2 diabetes might suggest an effect on atherosclerotic plaque vulnerability and/or thrombosis, in which myeloid angiogenic cells (MAC) and platelets (PLT) are implicated. We tested the effects of SGLT2i on inflammation and oxidant stress in a model of stearic acid (SA)-induced lipotoxicity in MAC and on PLT activation. The possible involvement of the Na+/H+ exchanger (NHE) was also explored.<br />info:eu-repo/semantics/published
- Subjects :
- lcsh:Diseases of the circulatory (Cardiovascular) system
Endocrinology, Diabetes and Metabolism
Glucosides -- pharmacology
Apoptosis
Stearic Acids -- toxicity
030204 cardiovascular system & hematology
Pharmacology
chemistry.chemical_compound
0302 clinical medicine
Glucosides
Blood Platelets -- drug effects -- metabolism -- pathology
Atherosclerosis
Myeloid angiogenic cells
Platelets
SGLT-2 inhibitors
Sodium-proton exchanger
Adenosine Diphosphate
Benzhydryl Compounds
Blood Platelets
Cells, Cultured
Endothelial Progenitor Cells
Humans
Inflammation Mediators
Oxidative Stress
Platelet Activation
Signal Transduction
Sodium-Glucose Transporter 2
Sodium-Glucose Transporter 2 Inhibitors
Sodium-Hydrogen Exchangers
Stearic Acids
Sodium-Glucose Transporter 2 Inhibitors -- pharmacology
Platelet
Sodium-Hydrogen Exchangers -- metabolism
Original Investigation
0303 health sciences
Cultured
Sciences bio-médicales et agricoles
Amiloride
Inflammation Mediators -- metabolism
Lipotoxicity
Sodium/Glucose Cotransporter 2
Adenosine Diphosphate -- pharmacology
Tumor necrosis factor alpha
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
Benzhydryl Compounds -- pharmacology
Cells
Inflammation
03 medical and health sciences
Oxidative Stress -- drug effects
Internal medicine
medicine
Platelet Activation -- drug effects
030304 developmental biology
Cariporide
business.industry
Sodium-Glucose Transporter 2 -- metabolism
chemistry
Endothelial Progenitor Cells -- drug effects -- metabolism -- pathology
lcsh:RC666-701
business
Apoptosis -- drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....db1d2ff06039e7052bef6fbb6960c97d