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Feasibility of stereotactic radiotherapy for lung lesions and conventional radiotherapy for nodal areas in primary lung malignancies
- Source :
- Radiation Oncology (London, England), Radiation Oncology, Vol 13, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer. Methods This study included 21 patients with small primary lung tumors distant from the regional nodal areas. The SBRT dose was 40–60 Gy in 4 fractions. CRT doses were 66 Gy in 30 fractions for non-small cell lung cancer and 52.5 Gy in 25 fractions for small cell lung cancer. Results The median follow-up duration was 12 months, and the median survival was 13 months. The 1 year overall survival, local recurrence-free survival, and distant metastasis-free survival rates were 60.5, 84.8, and 62.1%, respectively. Two patients experienced in-field local recurrence combined with out-field regional recurrence and/or distant failure. The major recurrence pattern was distant failure (crude incidence, 43%). Three patients aged ≥79 years experienced grade ≥ 3 acute radiation pneumonitis, and one also had idiopathic interstitial pneumonia. Conclusion The combination of SBRT for the lung lesion and CRT for the nodal region seems to be effective and safe for lung malignancies. However, patients older in age and/or with underlying pulmonary disease require stricter lung dose constraints.
- Subjects :
- lcsh:Medical physics. Medical radiology. Nuclear medicine
Male
medicine.medical_specialty
Lung Neoplasms
Survival
lcsh:R895-920
medicine.medical_treatment
Radiosurgery
lcsh:RC254-282
030218 nuclear medicine & medical imaging
Stereotactic radiotherapy
03 medical and health sciences
0302 clinical medicine
Conventional radiotherapy
Carcinoma, Non-Small-Cell Lung
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
Respiratory system
Lung cancer
Idiopathic interstitial pneumonia
Aged
Retrospective Studies
Aged, 80 and over
Lymphatic Irradiation
Lung
Radiotherapy
Toxicity
business.industry
Research
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Radiation therapy
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Feasibility Studies
Female
Dose Fractionation, Radiation
Radiology
Neoplasm Recurrence, Local
NODAL
business
Subjects
Details
- ISSN :
- 1748717X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology
- Accession number :
- edsair.doi.dedup.....db156717985c7e428332bcdc57661f38