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Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid
- Source :
- Pediatrics. 120(3)
- Publication Year :
- 2007
-
Abstract
- An 18-month-old boy was treated with an antibiotic containing pivalic acid for 6 months for intractable otitis media and then developed repeated convulsions and loss of consciousness. Laboratory data showed hypoglycemia and hypocarnitinemia. Intravenous administration of glucose was ineffective against the seizures and loss of consciousness. However, the patient regained consciousness and recovered soon after intravenous infusion of carnitine. To our knowledge, intravenous carnitine administration that contributed to marked improvements in neurologic deficit caused by administration of an antibiotic containing pivalic acid has not been reported previously. These findings indicate that long-term use of such antibiotics should be avoided.
- Subjects :
- Male
Pivalic acid
medicine.drug_class
Encephalopathy
Antibiotics
Unconsciousness
Hypoglycemia
chemistry.chemical_compound
Seizures
Carnitine
medicine
Humans
Infusions, Intravenous
Pentanoic Acids
Acidosis
business.industry
Brain Diseases, Metabolic
Infant
medicine.disease
Anti-Bacterial Agents
Cephalosporins
Otitis Media
Otitis
chemistry
Anesthesia
Pediatrics, Perinatology and Child Health
Vitamin B Complex
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 10984275
- Volume :
- 120
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pediatrics
- Accession number :
- edsair.doi.dedup.....dafe983b6fbe0c86b217efa725d614d2