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Sporadic Abdominal Wall Desmoid type Fibromatosis: treatment paradigm after thirty two years
- Source :
- BMC Surgery, Vol 18, Iss 1, Pp 1-7 (2018)
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Desmoid-type fibromatosis is a benign mesenchymal neoplastic process. It exhibits an uncertain growth pattern and high recurrence rate. Previously radical surgical resection was the mainstay of treatment, but recently more surgeons are opting for conservative management with observation (“wait and see” policy). The authors intend to evaluate different therapeutic modalities and oncological outcomes for abdominal wall desmoid tumors. Methods We performed a retrospective study of patients who underwent surgical, hormonal or chemotherapy treatment for abdominal wall desmoid tumors between 1982 to 2014 at two institutions affiliated with the University of São Paulo, Brazil. Results In the study period, 32 patients were included. Twenty-seven patients had surgery upfront. Of those, 89% were women with a median age of 33 years. Mean tumor size was 10 cm. Pathology confirmed free margins in 92% of resections. Tumor recurrence rate was 11%, with median relapse-free survival being 24 months. Multivariate analysis showed that positive final margins (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
lcsh:Surgery
Abdominal wall
Young Adult
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Abdominal wall desmoid
Desmoid tumor
Non aggressive management
Peritoneal Neoplasms
Aged
Retrospective Studies
Aged, 80 and over
Surgeons
Frozen section procedure
Chemotherapy
business.industry
Abdominal Wall
Fibromatosis
Retrospective cohort study
General Medicine
lcsh:RD1-811
Middle Aged
medicine.disease
Surgery
Radiation therapy
Fibromatosis, Aggressive
medicine.anatomical_structure
Watch and wait strategy
Response Evaluation Criteria in Solid Tumors
030220 oncology & carcinogenesis
Multivariate Analysis
Female
030211 gastroenterology & hepatology
Neoplasm Recurrence, Local
business
Brazil
Subjects
Details
- Language :
- English
- ISSN :
- 14712482
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Surgery
- Accession number :
- edsair.doi.dedup.....daee8a70f1b3be310455518e80f05119