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Epithelial-mesenchymal transition, and collective and individual cell migration regulate epithelial changes in the amikacin-damaged organ of Corti
- Source :
- Histochemistry and cell biology. 148(2)
- Publication Year :
- 2017
-
Abstract
- Characterizing the microenvironment of a damaged organ of Corti and identifying the basic mechanisms involved in subsequent epithelial reorganization are critical for improving the outcome of clinical therapies. In this context, we studied the expression of a variety of cell markers related to cell shape, cell adhesion and cell plasticity in the rat organ of Corti poisoned with amikacin. Our results indicate that, after severe outer hair cell losses, the cytoarchitectural reorganization of the organ of Corti implicates epithelial-mesenchymal transition mechanisms and involves both collective and individual cell migratory processes. The results also suggest that both root cells and infiltrated fibroblasts participate in the homeostasis of the damaged epithelium, and that the flat epithelium that may emerge offers biological opportunities for late regenerative therapies.
- Subjects :
- 0301 basic medicine
Histology
Epithelial-Mesenchymal Transition
Context (language use)
Biology
03 medical and health sciences
Cell Movement
Cell Plasticity
otorhinolaryngologic diseases
medicine
Animals
Epithelial–mesenchymal transition
Rats, Wistar
Cell adhesion
Molecular Biology
Amikacin
Organ of Corti
Cochlea
Cell migration
Epithelial Cells
Cell Biology
Cell biology
Rats
Medical Laboratory Technology
030104 developmental biology
medicine.anatomical_structure
Hair cell
Subjects
Details
- ISSN :
- 1432119X
- Volume :
- 148
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Histochemistry and cell biology
- Accession number :
- edsair.doi.dedup.....dae8c5286ad955af9d4e7540c3fe8997