Back to Search
Start Over
Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor
- Source :
- Science. 257:1089-1095
- Publication Year :
- 1992
- Publisher :
- American Association for the Advancement of Science (AAAS), 1992.
-
Abstract
- Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA residues within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of specificity of action of homeodomain proteins in development.
- Subjects :
- Serum Response Factor
Molecular Sequence Data
EMX2
Saccharomyces cerevisiae
Biology
Transfection
DNA-binding protein
NKX2-3
Fungal Proteins
Serum response factor
Animals
Drosophila Proteins
Humans
Amino Acid Sequence
Transcription factor
Homeodomain Proteins
Genetics
Fungal protein
Binding Sites
Multidisciplinary
Base Sequence
Nuclear Proteins
DNA
NKX-homeodomain factor
Minichromosome Maintenance 1 Protein
Cell biology
DNA-Binding Proteins
Homeobox
Drosophila
Transcription Factors
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 257
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....dad6100aeb69a020bd9817913f746669