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Inhibitory Effects of Diallyl Bisulfide or Aspirin on 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine-induced Mammary Carcinogenesis in Rats
- Source :
- Japanese Journal of Cancer Research : Gann
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- Modifying effects of diallyl disulfide (DAD), aspirin or DL-alpha-difluoromethylornithine (DFMO) on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in SD rats were investigated. A total of 166 female rats, 6 weeks old, were divided into 8 groups. They were fed a high fat diet throughout the experiment. Starting at 7 weeks of age, groups 1-4 were given PhIP (85 mg/kg body weight in corn oil) by gavage 8 times in 10 days, and groups 5-8 were given corn oil alone. For the beginning 4 weeks, groups 2 and 5 were given DAD at 200 ppm in diet. Similarly groups 3 and 6, and groups 4 and 7 were given aspirin (400 ppm) and DFMO (400 ppm), respectively. Mammary carcinomas were only recognized in groups 1-4 at the termination (25 weeks after the start of experiment). Multiplicity (mean number/rat) of neoplasms in group 2 (PhIP+DAD, 0.90/rat) and group 3 (PhIP+aspirin, 1.37/rat) was significantly smaller than that in group 1 (PhIP alone, 2.45/ rat) (P < 0.005 and P < 0.05, respectively). These results indicate that dietary intake of DAD or aspirin during the time corresponding to initiation phase has chemopreventive potential on PhIP-induced mammary carcinogenesis in rats.
- Subjects :
- Cancer Research
medicine.medical_specialty
Eflornithine
Mammary gland
Administration, Oral
medicine.disease_cause
Chemoprevention
Article
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
medicine
Animals
Anticarcinogenic Agents
Disulfides
Anticarcinogen
Carcinogen
Aspirin
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Diallyl disulfide
Imidazoles
Mammary Neoplasms, Experimental
Dietary Fats
Rats
Allyl Compounds
medicine.anatomical_structure
Endocrinology
Oncology
chemistry
Carcinogens
Female
Corn Oil
Carcinogenesis
Mammary carcinogenesis
Corn oil
PhIP
medicine.drug
Subjects
Details
- ISSN :
- 09105050
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Cancer Research
- Accession number :
- edsair.doi.dedup.....dad1e6dc4eb04278e986becbe95325cd