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Increased expression of histone deacetylase 2 is found in human gastric cancer
- Source :
- APMIS. 113:264-268
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Accumulated evidence has established that aberrant regulation of histone deacetylases (HDACs) is one of the major causes of the development of human malignancies. Among different iso-enzymes of HDAC and sirtuins grouped as the HDAC super family, little is known as to how histone deacetylase 2 (HDAC2) causes carcinogenesis in solid tumors. Here, in order to investigate the possible role of HDAC2 in gastric carcinogenesis, we analyzed the expression of HDAC2 in 71 gastric adenocarcinomas by immunohistochemistry. Moderate to strong expression of HDAC2 was found in 44 (62%) out of a total of 71 tumors. The majority of positive tumors, which were detected in the nucleus but not in normal gastric epithelium, did not express HDAC2 or showed only weak positive staining. Interestingly, we also noted that HDAC2 expression appeared to be associated with tumor aggressiveness as HDAC2 expression was observed to be statistically significant in advanced gastric cancer (P=0.0023, Chi-square test) and in positive lymph node metastasis (P=0.0713, Chi-square test). Taken together, these results suggest that HDAC2 may play an important role in the aggressiveness of gastric cancer.
- Subjects :
- Microbiology (medical)
Pathology
medicine.medical_specialty
Histone Deacetylase 2
Adenocarcinoma
medicine.disease_cause
Histone Deacetylases
Pathology and Forensic Medicine
Metastasis
Stomach Neoplasms
medicine
Gastric mucosa
Humans
Immunology and Allergy
Neoplasm Invasiveness
Stomach cancer
Cell Nucleus
biology
Histone deacetylase 2
Cancer
General Medicine
medicine.disease
Immunohistochemistry
Repressor Proteins
Histone
medicine.anatomical_structure
Gastric Mucosa
biology.protein
Cancer research
Carcinogenesis
Subjects
Details
- ISSN :
- 16000463 and 09034641
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- APMIS
- Accession number :
- edsair.doi.dedup.....dac110c083345f1aaa25401fbbd733ae