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COVID-19, cardiovascular diseases and cardiac troponins
- Source :
- Future Cardiology
- Publication Year :
- 2022
- Publisher :
- Future Medicine Ltd, 2022.
-
Abstract
- There has been strong evidence of myocardial injury in coronavirus disease 2019 (COVID-19) patients with significantly elevated serum cardiac troponin (cTn). While the exact mechanism of injury is unclear, possible suggested pathological mechanisms of injury are discussed. These include increased susceptibility of the myocardium and endothelium to viral invasion, underlying hyperinflammatory state and subsequent cytokine storm, a hypercoagulable and prothrombotic state, and indirect myocardial injury due to hypoxemia. As a result of these pathological mechanisms in COVID-19 patients, cTn may be elevated largely due to myocarditis, microangiopathy or myocardial infarction. The utility of cTn as a biomarker for measuring myocardial injury in these patients and assessing its ability as a prognostic factor for clinical outcome is also discussed.
- Subjects :
- medicine.medical_specialty
Myocarditis
Coronavirus disease 2019 (COVID-19)
Endothelium
Myocardial Infarction
Review
Hypoxemia
cardiac troponin
Internal medicine
medicine
Humans
Myocardial infarction
Pathological
health care economics and organizations
business.industry
COVID-19
medicine.disease
Troponin
medicine.anatomical_structure
Cardiovascular Diseases
Cardiology
Molecular Medicine
Biomarker (medicine)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Cytokine storm
Biomarkers
Subjects
Details
- ISSN :
- 17448298 and 14796678
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Future Cardiology
- Accession number :
- edsair.doi.dedup.....daaa2d3d47e4ea37fc0c48a7b04ccbf2