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Monocyte chemoattractant protein 1 in obesity and insulin resistance
- Source :
- Proceedings of the National Academy of Sciences. 100:7265-7270
- Publication Year :
- 2003
- Publisher :
- Proceedings of the National Academy of Sciences, 2003.
-
Abstract
- This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (IR) 3T3-L1 adipocytes and in vivo in IR obese mice ( ob / ob ). Thus, MCP-1 resembles other previously described genes (e.g., PAI-1 and SREBP-1c ) that remain sensitive to insulin in IR states. The hyperinsulinemia that frequently accompanies obesity and insulin resistance may therefore contribute to the altered expression of these and other genes in insulin target tissues. In vivo studies also demonstrate that MCP-1 is overexpressed in obese mice compared with their lean controls, and that white adipose tissue is a major source of MCP-1. The elevated MCP-1 may alter adipocyte function because addition of MCP-1 to differentiated adipocytes in vitro decreases insulin-stimulated glucose uptake and the expression of several adipogenic genes ( LpL, adipsin, GLUT-4, aP2 , β3-adrenergic receptor, and peroxisome proliferator-activated receptor γ). These results suggest that elevated MCP-1 may induce adipocyte dedifferentiation and contribute to pathologies associated with hyperinsulinemia and obesity, including type II diabetes.
- Subjects :
- medicine.medical_specialty
FGF21
medicine.medical_treatment
Gene Expression
Mice, Obese
White adipose tissue
Biology
Mice
chemistry.chemical_compound
Insulin resistance
Adipocyte
Internal medicine
Adipocytes
medicine
Hyperinsulinemia
Animals
Insulin
Obesity
RNA, Messenger
Chemokine CCL2
Multidisciplinary
Cell Differentiation
3T3 Cells
Biological Sciences
medicine.disease
Mice, Inbred C57BL
Insulin receptor
Endocrinology
chemistry
Adipogenesis
biology.protein
Female
Insulin Resistance
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....daa2571246186ad10bd78b6ab61c59e4