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Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed microtomography (SR-μCT) was utilized to visualize and quantify the morphology of thousands crystalline particles of CLP I and CLP II before and after compression. As a result, the deformation was examined across scale dimensions from microns to the size of the final dosage form. Three dimensional parameters such as volume, sphericity, oblate and prolate of individual particle and distributions were computed and analyzed for quantitative comparison to CLP I and CLP II. The different degrees of deformation under the same compression conditions of CLP I and CLP II were observed and characterized quantitatively. The map of deformation degrees within the tablet illustrated the heterogeneous pressure distribution in various regions of the compacted tablet. In conclusion, the polymorph deformation behaviors demonstrated by SR-μCT quantitative structure analysis deepen understanding of tableting across dimensions from microns to millimeters for the macrostrcuture of tablet.
- Subjects :
- Ticlopidine
Materials science
Compressive Strength
Drug Compounding
Mineralogy
Synchrotron radiation
02 engineering and technology
Deformation (meteorology)
030226 pharmacology & pharmacy
Article
Dosage form
Sphericity
03 medical and health sciences
Tableting
0302 clinical medicine
X-Ray Diffraction
Pressure
Composite material
Multidisciplinary
Clopidogrel Bisulfate
X-Ray Microtomography
021001 nanoscience & nanotechnology
Compression (physics)
Clopidogrel
Microscopy, Electron, Scanning
Particle
Crystallization
0210 nano-technology
Tablets
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....da9834383204ca86ca91cc846b46c3c5
- Full Text :
- https://doi.org/10.1038/srep21770