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Symptomatic recovery and pharmacological management in a clinical cohort with peripartum cardiomyopathy
- Source :
- The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 31(10)
- Publication Year :
- 2017
-
Abstract
- We aimed to characterize the clinical course with focus on pharmacological management of peripartum cardiomyopathy (PPCM) in Sweden.Twenty-four consecutive patients were retrospectively identified among women presenting with PPCM in Western Sweden. Of these, 14 had concomitant preeclampsia. There was only one fatality. The mean (standard deviation) left ventricular ejection fraction (LVEF) at diagnosis was 35.0 ± 9.9%. Ten women, 47.6%, required intensive care unit (ICU) admission. All patients received β-blockers (BB) and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACE-I/ARB), which were tapered off over a mean/median period of 3.3/2.5 years with only one case of worsening heart failure. The mean follow-up for medication was 7.9 ± 2.6 years. Early and late/non-recovery was defined as New York Heart Association (NYHA) functional class I and NYHA II-IV at one year, respectively. Late recovery was associated with larger LVEDD at diagnosis (56.8 versus 62.4 mm) was associated with late recovery, p = .02.PPCM had an overall good prognosis in this cohort. Left ventricular dilation at presentation was a predictor of worse prognosis. Concurrent preeclampsia was common, but was associated with better prognosis. Medication was safely discontinued in 75% of patients.
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Peripartum cardiomyopathy
Clinical cohort
Pharmacological management
Adrenergic beta-Antagonists
Pregnancy Complications, Cardiovascular
Cardiomyopathy
Angiotensin-Converting Enzyme Inhibitors
030204 cardiovascular system & hematology
Statistics, Nonparametric
Ventricular Function, Left
Pharmacological treatment
03 medical and health sciences
0302 clinical medicine
Pregnancy
Internal medicine
Medicine
Humans
030212 general & internal medicine
reproductive and urinary physiology
Retrospective Studies
business.industry
Clinical course
Infant, Newborn
Pregnancy Outcome
Obstetrics and Gynecology
medicine.disease
female genital diseases and pregnancy complications
humanities
body regions
Intensive Care Units
Echocardiography
Heart failure
Pediatrics, Perinatology and Child Health
Cardiology
Female
business
Cardiomyopathies
Subjects
Details
- ISSN :
- 14764954
- Volume :
- 31
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Accession number :
- edsair.doi.dedup.....da97f5c42699bf719fbd674880bb1718