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Long noncoding RNA and protein abundance in lncRNPs
- Source :
- RNA
- Publication Year :
- 2021
-
Abstract
- Although long noncoding RNAs (lncRNAs) are generally expressed at low levels, emerging evidence has revealed that many play important roles in gene regulation by a variety of mechanisms as they engage with proteins. Given that the abundance of proteins often greatly exceeds that of their interacting lncRNAs, quantification of the relative abundance, or even the exact stoichiometry in some cases, within lncRNA–protein complexes is helpful for understanding of the mechanism(s) of action of lncRNAs. We discuss methods used to examine lncRNA and protein expression at the single cell, subcellular, and suborganelle levels, the average and local lncRNA concentration in cells, as well as how lncRNAs can modulate the functions of their interacting proteins even at a low stoichiometric concentration.
- Subjects :
- Regulation of gene expression
Mechanism (biology)
Cell
RNA-Binding Proteins
Computational biology
Review
Biology
Protein expression
Long non-coding RNA
medicine.anatomical_structure
Gene Expression Regulation
Ribonucleoproteins
Abundance (ecology)
medicine
Animals
Humans
RNA, Long Noncoding
Protein abundance
Molecular Biology
Subjects
Details
- ISSN :
- 14699001
- Volume :
- 27
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- RNA (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....da7ce4635bf78c8313116b01eead97d3