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A randomized double-blind study of fluoxetine versus placebo in the treatment of dysthymia
- Source :
- The American journal of psychiatry. 150(8)
- Publication Year :
- 1993
-
Abstract
- The purpose of this study was to assess the efficacy of fluoxetine, a selective serotonergic antidepressant, in the treatment of dysthymia.Thirty-five patients who met criteria for dysthymia, but not major depression, began randomized, double-blind 8-week trials of fluoxetine or placebo.Of 32 patients who completed the study, 10 (62.5%) of the 16 patients given fluoxetine and three (18.8%) of the 16 given placebo responded to treatment. Response was defined as 1) 50% or greater decrease in Hamilton Rating Scale for Depression score and 2) a score of 1 or 2 on the Clinical Global Impression (CGI) improvement subscale. Fluoxetine subjects showed significantly greater improvement at week 8 than placebo subjects on the Hamilton depression and CGI scales, but not on the Hopkins Symptom Check-list (58-item) or the Cornell Dysthymia Rating Scale.When compared to placebo, fluoxetine showed short-term effectiveness in treating dysthymic symptoms.
- Subjects :
- Adult
Male
Personality Inventory
Placebo
Serotonergic
law.invention
Placebos
Randomized controlled trial
Double-Blind Method
law
Fluoxetine
medicine
Humans
Depression (differential diagnoses)
Psychiatric Status Rating Scales
Depressive Disorder
business.industry
Clinical trial
Psychiatry and Mental health
Anesthesia
Antidepressant
Female
Reuptake inhibitor
business
medicine.drug
Subjects
Details
- ISSN :
- 0002953X
- Volume :
- 150
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The American journal of psychiatry
- Accession number :
- edsair.doi.dedup.....da7167bb9419b9334d0ac79469d92c91