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Influence of age, frailty and liver function on the pharmacokinetics of brofaromine
- Source :
- European Journal of Clinical Pharmacology. 49:387-391
- Publication Year :
- 1996
- Publisher :
- Springer Science and Business Media LLC, 1996.
-
Abstract
- The pharmacokinetics of brofaromine, a selective inhibitor of monoamine oxidase A, was evaluated in 12 frail elderly patients (66-92 y) and 12 healthy volunteers (20-35 y).Quantitative liver function tests were performed to show whether brofaromine elimination in the elderly could be predicted from noninvasive assessment of CYP1A2 activity (caffeine clearance) or liver plasma flow (sorbitol clearance).In the elderly the AUC of brofaromine was significantly increased (e.g. for the 75 mg dose 43.2 vs 19.9 mumol*h.l-1, clearance was reduced (5.0 vs. 11.8 l.h-1), the volume of distribution was smaller (130 vs. 230 l), and the half-life was slightly increased (19.0 vs. 14.2 h). No significant correlation was observed between hepatic plasma flow and brofaromine clearance (r = 0.41, P = 0.05), whereas CYP1A2 activity and brofaromine clearance were tightly correlated (r = 0.94, P0.0001).Caffeine clearance, a simple, noninvasive test of CYP1A2 activity, is predictive of brofaromine clearance.
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
Chromatography, Gas
Monoamine Oxidase Inhibitors
Frail Elderly
health care facilities, manpower, and services
Administration, Oral
Pharmacology
chemistry.chemical_compound
Liver Function Tests
Piperidines
Pharmacokinetics
Cytochrome P-450 CYP1A2
Caffeine
Internal medicine
Brofaromine
medicine
Humans
Sorbitol
Pharmacology (medical)
Aged
Aged, 80 and over
Geriatrics
Cross-Over Studies
biology
medicine.diagnostic_test
business.industry
CYP1A2
General Medicine
Crossover study
Endocrinology
chemistry
biology.protein
Regression Analysis
Female
Liver function
Monoamine oxidase A
business
Liver function tests
Half-Life
Subjects
Details
- ISSN :
- 14321041 and 00316970
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....da70db872a6712037d9779c7e47d4d95