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High-Dose Continuous Infusion Plus Pulse Interleukin-2 and Famotidine in Melanoma
- Source :
- Cancer Biotherapy and Radiopharmaceuticals. 19:770-775
- Publication Year :
- 2004
- Publisher :
- Mary Ann Liebert Inc, 2004.
-
Abstract
- High-dose, continuous infusion interleukin-2 (IL-2) regimens generate greater Lymphokine Activated Killer cell (LAK) cytotoxicity in vitro and a higher rebound lymphocytosis in vivo than do bolus IL-2 regimens. Lymphocytes initially activated by continuous infusion IL-2 then subsequently pulsed with IL-2 have increased cytotoxicity against cancer cells. Famotidine may enhance the lysis of tumors by cytotoxic lymphocytes. Fourteen patients with melanoma were treated with famotidine 20 mg intravenously twice per day and continuous infusion IL-2 (18 MIU/sq m/24 hours) for 72 hours, followed by a 24-hour rest, then IL-2 18 MIU/sq m over 15-30 minutes for 1 dose (12 patients) or daily for 3 doses (2 patients). Most common toxicities were fever, nausea/emesis, hypophosphatemia, hypomagnesemia, and rigors. Nine partial responses (64% response rate; 95% Confidence Interval: 39%-84%) have been seen. Median survival has not been reached at greater than 10 months. Two patients responding to therapy showed an increase in detectable CD 56(+) cells in serial subcutaneous or lymph node biopsies, while 1 patient undergoing progression of disease had no such infiltrate. High-dose, 72-hour continuous infusion plus pulse interleukin-2 with famotidine has activity in melanoma. CD 56(+) cells may play a role in responding patients.
- Subjects :
- Adult
Male
Interleukin 2
Cancer Research
Lung Neoplasms
Skin Neoplasms
Lymphocytosis
Continuous infusion
Immunology
Antineoplastic Agents
Bone Neoplasms
chemical and pharmacologic phenomena
Pharmacology
Bolus (medicine)
In vivo
medicine
Humans
Immunology and Allergy
Radiology, Nuclear Medicine and imaging
Infusions, Intravenous
Pulse
Melanoma
Aged
Lymphokine-activated killer cell
Pulse (signal processing)
business.industry
Liver Neoplasms
General Medicine
Middle Aged
Famotidine
medicine.disease
Oncology
Interleukin-2
Drug Therapy, Combination
Female
Lymph Nodes
medicine.symptom
business
T-Lymphocytes, Cytotoxic
medicine.drug
Subjects
Details
- ISSN :
- 15578852 and 10849785
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Cancer Biotherapy and Radiopharmaceuticals
- Accession number :
- edsair.doi.dedup.....da69b10b25742ad36dda78e694fc92bd