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Polymorphisms in XPC and ERCC2 genes, smoking and breast cancer risk
- Source :
- International Journal of Cancer. 122:2101-2105
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- To evaluate the associations of breast cancer risk with polymorphisms in the XPC and XPD/ERCC2 DNA nucleotide excision repair genes, a case-control study nested within a prospective cohort of 14,274 women was conducted. Genotypes were characterized for 612 incident, invasive breast cancer cases and their 1:1 matched controls. The homozygous variant of a poly(AT) insertion/deletion polymorphism in intron 9 of the XPC gene (XPC-PAT+/+), was associated with breast cancer risk [odds ratio (OR) = 1.45, 95% confidence interval: 1.07-1.97], after adjustment for other breast cancer risk factors. The breast cancer risk associated with XPC-PAT+/+ did not differ by age at diagnosis. There was an indication of an interaction (p = 0.08) between the XPC-PAT+/+ genotype and cigarette smoking. Ever smokers with the XPC-PAT+/+ genotype were at elevated risk of breast cancer (OR = 1.56, CI: 0.95-2.58), but no differences were observed among never smokers. Analyses of the ERCC2 Lys751Gln polymorphism did not show an association with breast cancer risk, either overall or at younger ages. The results suggest that breast cancer risk is related to the XPC haplotype tagged by the XPC-PAT+/+ insertion-deletion polymorphism in intron 9. Further study of the XPC haplotypes and their interactions with smoking in relation to breast cancer risk is needed.
- Subjects :
- Adult
Oncology
Cancer Research
medicine.medical_specialty
Alcohol Drinking
Genotype
Matched-Pair Analysis
Breast Neoplasms
Biology
Risk Assessment
White People
Cohort Studies
Breast cancer
Risk Factors
Surveys and Questionnaires
Internal medicine
Odds Ratio
medicine
Humans
Prospective cohort study
Xeroderma Pigmentosum Group D Protein
Genetics
Polymorphism, Genetic
Smoking
Haplotype
Cancer
Odds ratio
Middle Aged
medicine.disease
Black or African American
DNA-Binding Proteins
Jews
ERCC2
Female
Nucleotide excision repair
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....da60c9fadf9e8c9c040d4a67e1558e60