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Determination of Sulfonylureas and Metabolites by Pyrolysis Gas Chromatography
- Source :
- Clinical Chemistry. 20:200-204
- Publication Year :
- 1974
- Publisher :
- Oxford University Press (OUP), 1974.
-
Abstract
- We describe a simple, rapid method for determination of sulfonylureas that is not susceptible to significant interference from metabolites. An acidified plasma is extracted with toluene, followed by a back extraction from the toluene to methanolic trimethylanilinium hydroxide. The resulting compounds are measured by gas chromatography.
- Subjects :
- Chlorpropamide
Chromatography, Gas
Time Factors
Tolbutamide
Clinical Biochemistry
Chlorobenzenes
Mass Spectrometry
Structure-Activity Relationship
chemistry.chemical_compound
Methods
Humans
Pentobarbital
Sulfonamides
Chromatography
Chemistry
Biochemistry (medical)
Extraction (chemistry)
Tolazamide
Secobarbital
Toluene
Sulfonylurea Compounds
Evaluation Studies as Topic
Phenobarbital
Amobarbital
Hydroxide
Gas chromatography
Pyrolysis
Subjects
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi.dedup.....da52ca595ec597ef6c6944dbe41865d5
- Full Text :
- https://doi.org/10.1093/clinchem/20.2.200