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Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions

Authors :
Tobias Ankner
Michael Grigalunas
Olaf Wiest
Per-Ola Norrby
Paul Helquist
Source :
Organic Letters. 16:3970-3973
Publication Year :
2014
Publisher :
American Chemical Society (ACS), 2014.

Abstract

A protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates has been developed using a Pd/Q-Phos catalyst. Efficient intermolecular coupling of a variety of ketones with alkenyl bromides was achieved with a slight excess of LiHMDS and temperatures down to 0 °C.

Details

ISSN :
15237052 and 15237060
Volume :
16
Database :
OpenAIRE
Journal :
Organic Letters
Accession number :
edsair.doi.dedup.....da3f93400a4d33ee6b5f3c34381d883d