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GDNF is not required for catecholaminergic neuron survival in vivo
- Publication Year :
- 2015
-
Abstract
- Glial cell line-derived neurotrophic factor (GDNF) has been tested in clinical trials to treat Parkinson’s disease with promising but variable results. Improvement of therapeutic effectiveness requires solid understanding of the physiological role of GDNF in the maintenance of the adult brain catecholamine system. However, existing data on this issue is contradictory. Here we show with three complementary approaches that, independent of the time of reduction, Gdnf is not required for maintenance of catecholaminergic neurons in adult mice.
- Subjects :
- Nervous system
animal diseases
Molecular neuroscience
Article
03 medical and health sciences
0302 clinical medicine
Catecholamines
In vivo
Neurotrophic factors
Glial cell line-derived neurotrophic factor
medicine
Animals
Glial Cell Line-Derived Neurotrophic Factor
030304 developmental biology
Catecholaminergic
Neurons
0303 health sciences
biology
urogenital system
General Neuroscience
Brain
medicine.anatomical_structure
nervous system
Gene Expression Regulation
biology.protein
Catecholamine
Catecholaminergic cell groups
Psychology
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....da3cfce84c11773379f2b32209311041