Back to Search
Start Over
Synthesis and In Vitro Characterization of Fe3+-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System
- Source :
- Materials, Vol 10, Iss 10, p 1140 (2017), Materials, Materials; Volume 10; Issue 10; Pages: 1140
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Highly dispersed Fe3+-doped layered double hydroxide (LDH-Fe) nanorings were obtained by a simple coprecipitation-acid etching approach. The morphology, structure, magnetic resonance imaging (MRI) performance in vitro, drug loading and releasing, Fe3+ leakage, and cytotoxicity of the as-prepared LDH-Fe nanorings were characterized. The LDH-Fe nanorings showed good water dispersity and a well-crystallized structure. The DLS average size of nanoparticles was measured to be 94.5 nm. Moreover, the MRI tests showed a favourable T1-weighted MRI performance of the LDH-Fe nanoring with r1 values of 0.54 and 1.68, and low r2/r1 ratios of 10.1 and 6.3, pre- and after calcination, respectively. The nanoparticles also showed high model drug (ibuprofen) loading capacities, low Fe3+ leakage, and negligible cytotoxicity. All these results demonstrate the potential of LDH-Fe nanorings as an imageable drug delivery system.
- Subjects :
- Nanostructure
Materials science
nanostructure
Dispersity
Nanoparticle
Nanotechnology
02 engineering and technology
engineering.material
010402 general chemistry
01 natural sciences
lcsh:Technology
Article
chemistry.chemical_compound
General Materials Science
drug carrier
layered double hydroxides
MRI
lcsh:Microscopy
lcsh:QC120-168.85
lcsh:QH201-278.5
lcsh:T
Layered double hydroxides
021001 nanoscience & nanotechnology
0104 chemical sciences
Chemical engineering
chemistry
lcsh:TA1-2040
Drug delivery
engineering
Hydroxide
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
0210 nano-technology
Drug carrier
lcsh:Engineering (General). Civil engineering (General)
lcsh:TK1-9971
Nanoring
Subjects
Details
- Language :
- English
- ISSN :
- 19961944
- Volume :
- 10
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Materials
- Accession number :
- edsair.doi.dedup.....da3b888cf11f49024a943d6bbe534809